{"id":12043,"date":"2026-09-11T09:25:01","date_gmt":"2026-09-11T09:25:01","guid":{"rendered":"https:\/\/www.musclestationth.com\/?p=12043"},"modified":"2026-09-11T09:25:01","modified_gmt":"2026-09-11T09:25:01","slug":"thymosin-alpha-1","status":"publish","type":"post","link":"https:\/\/www.musclestationth.com\/en\/thymosin-alpha-1\/","title":{"rendered":"What is Thymosin Alpha-1? Thymalfasin evidence and Thai records"},"content":{"rendered":"<p>Thymosin alpha-1 (T\u03b11) is a 28-amino-acid peptide involved in immune-response regulation. Its synthetic form is called thymalfasin; ZADAXIN is one trade name. Findings in specific patient groups do not establish general immune-boosting or anti-aging benefits.<\/p><h2>How do thymosin alpha-1, thymalfasin and ZADAXIN differ?<\/h2><p>Thymosin alpha-1 names the peptide, thymalfasin names its synthetic form, and ZADAXIN identifies a branded medicine. ZADAXIN product information hosted by Indonesia\u2019s medicines regulator describes chemically synthesized thymosin alpha-1. Substance identity and product identity should therefore be checked separately. <a href=\"https:\/\/registrasiobat.pom.go.id\/files\/assesment-reports\/obat_baru\/Zadaxin.pdf\">BPOM Indonesia \u2014 ZADAXIN product information<\/a><\/p><h2>Is it the same as thymosin beta-4 or TB-500?<\/h2><p>No. Thymosin alpha-1 and thymosin beta-4 are different substances. A listing called TB-500 also needs its own label checked. Sharing part of a name does not make their evidence interchangeable.<\/p><h2>What do human studies show?<\/h2><h3>TESTS, 2025: sepsis outcomes<\/h3><p>This double-blind, placebo-controlled randomized trial enrolled 1,106 patients with sepsis at 22 Chinese centers. It did not show clear evidence that thymosin alpha-1 reduced mortality at 28 days. It did not test wellness use in healthy people. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39814420\/\">Wu et al., 2025 \u2014 TESTS randomized phase 3 sepsis trial<\/a><\/p><p>A correction was published on 30 May 2025. Both the main report and correction are linked so readers can consult the complete publication record. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40447307\/\">BMJ, 30 May 2025 \u2014 Correction to the TESTS trial<\/a><\/p><h3>GATES, 2026: one component of cancer treatment<\/h3><p>An open-label phase 2 study of 30 patients with gastric or gastroesophageal-junction cancer reported pathological responses after treatment involving several medicines, including thymalfasin. Without a randomized comparison isolating thymalfasin, the study cannot establish how much it contributed. It is not evidence for cancer prevention. <a href=\"https:\/\/link.springer.com\/article\/10.1186\/s12916-026-04740-z\">Xu et al., 2026 \u2014 GATES prospective gastric cancer study<\/a><\/p><h2>Is there a Thai registration record?<\/h2><p>The Thai FDA database displays ZADAXIN, registration <strong>1C 94\/49(NB)<\/strong>, with thymalfasin (thymosin alpha1), sterile powder, manufacturer PATHEON ITALIA S.p.A in Italy, and DKSH (Thailand) Ltd as license holder. <a href=\"https:\/\/ndi.fda.moph.go.th\/drug_detail\/index\/?rcno=4900094&amp;rctype=1C&amp;register=MUMgOTQvNDkoTkIp\">Thai FDA \u2014 ZADAXIN, 1C 94\/49(NB); database dated 30 June 2025<\/a><\/p><p><strong>The database is dated 30 June 2025.<\/strong> Finding this entry does not confirm today\u2019s registration status, availability, or the authenticity of another seller\u2019s T\u03b11 vial. Indications in foreign product information should not automatically be described as Thai-approved indications.<\/p><h2>What should be checked for an actual product?<\/h2><p>Check the label, trade name, manufacturer, formulation, batch number and matching documentation. Thymalfasin studies and a ZADAXIN registration do not verify another brand\u2019s quality or effects. A research label or analytical certificate alone does not establish authorization for human use.<\/p><p>ZADAXIN information lists hypersensitivity as a contraindication and includes important restrictions for people deliberately immunosuppressed, such as transplant recipients. Immune-related treatment requires assessment of the condition and current medicines; more immune stimulation is not automatically beneficial. <a href=\"https:\/\/registrasiobat.pom.go.id\/files\/assesment-reports\/obat_baru\/Zadaxin.pdf\">BPOM Indonesia \u2014 ZADAXIN product information<\/a><\/p><h2>Frequently asked questions<\/h2><h3>Are thymosin alpha-1 and thymalfasin the same name?<\/h3><p>Thymalfasin refers to synthetic thymosin alpha-1. ZADAXIN is one trade name; each product still needs separate identification.<\/p><h3>Can thymosin alpha-1 replace TB-500?<\/h3><p>They should not be treated as interchangeable. The names do not identify the same substance, and evidence cannot be transferred between them.<\/p><h3>Is ZADAXIN listed in the Thai database?<\/h3><p>Yes. Entry 1C 94\/49(NB) appears in the Thai FDA database dated 30 June 2025. This does not confirm current status or an individual seller\u2019s product.<\/p><h3>Are general immune-boosting and anti-aging benefits established?<\/h3><p>The cited studies involve specific patient groups. They do not establish those general benefits or the effects of every brand.<\/p><h2>Related reading<\/h2><ul><li><a href=\"https:\/\/www.musclestationth.com\/en\/product-category\/type\/peptide\/tb500-bpc157\/\">BPC-157 and TB-500: substance identity and evidence<\/a><\/li><\/ul><h2>General information enquiries<\/h2><p>For questions about names, labels or documents, contact LINE: <a href=\"https:\/\/line.me\/R\/ti\/p\/%40musclestationth\">@musclestationth<\/a>. Personal treatment decisions require a qualified healthcare professional.<\/p><h2>Primary sources<\/h2><ul><li><a href=\"https:\/\/registrasiobat.pom.go.id\/files\/assesment-reports\/obat_baru\/Zadaxin.pdf\">BPOM Indonesia \u2014 ZADAXIN product information<\/a><\/li><li><a href=\"https:\/\/ndi.fda.moph.go.th\/drug_detail\/index\/?rcno=4900094&amp;rctype=1C&amp;register=MUMgOTQvNDkoTkIp\">Thai FDA \u2014 ZADAXIN, 1C 94\/49(NB); database dated 30 June 2025<\/a><\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39814420\/\">Wu et al., 2025 \u2014 TESTS randomized phase 3 sepsis trial<\/a><\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40447307\/\">BMJ, 30 May 2025 \u2014 Correction to the TESTS trial<\/a><\/li><li><a href=\"https:\/\/link.springer.com\/article\/10.1186\/s12916-026-04740-z\">Xu et al., 2026 \u2014 GATES prospective gastric cancer study<\/a><\/li><\/ul><p>Information checked: 11 September 2026. Educational information; no seller\u2019s product or batch has been authenticated.<\/p>","protected":false},"excerpt":{"rendered":"<p>Thymosin alpha-1 (T\u03b11) is a 28-amino-acid peptide involved in immune-response regulation. Its synthetic form is called thymalfasin; ZADAXIN is one trade name. Findings in specific patient groups do not establish general immune-boosting or anti-aging benefits.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":true,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[281],"tags":[],"class_list":["post-12043","post","type-post","status-publish","format-standard","hentry","category-281"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","rttpg_featured_image_url":null,"rttpg_author":{"display_name":"admin","author_link":"https:\/\/www.musclestationth.com\/en\/author\/musclestationth\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/www.musclestationth.com\/en\/category\/%e0%b8%9a%e0%b8%97%e0%b8%84%e0%b8%a7%e0%b8%b2%e0%b8%a1%e0%b8%97%e0%b8%b5%e0%b9%88%e0%b8%99%e0%b9%88%e0%b8%b2%e0%b8%aa%e0%b8%99%e0%b9%83%e0%b8%88\/\" rel=\"category tag\">\u0e1a\u0e17\u0e04\u0e27\u0e32\u0e21\u0e17\u0e35\u0e48\u0e19\u0e48\u0e32\u0e2a\u0e19\u0e43\u0e08<\/a>","rttpg_excerpt":"Thymosin Alpha-1 \u0e2b\u0e23\u0e37\u0e2d T\u03b11 \u0e40\u0e1b\u0e47\u0e19\u0e40\u0e1b\u0e1b\u0e44\u0e17\u0e14\u0e4c 28 \u0e01\u0e23\u0e14\u0e2d\u0e30\u0e21\u0e34\u0e42\u0e19\u0e17\u0e35\u0e48\u0e40\u0e01\u0e35\u0e48\u0e22\u0e27\u0e02\u0e49\u0e2d\u0e07\u0e01\u0e31\u0e1a\u0e01\u0e32\u0e23\u0e1b\u0e23\u0e31\u0e1a\u0e01\u0e32\u0e23\u0e15\u0e2d\u0e1a\u0e2a\u0e19\u0e2d\u0e07\u0e02\u0e2d\u0e07\u0e20\u0e39\u0e21\u0e34\u0e04\u0e38\u0e49\u0e21\u0e01\u0e31\u0e19 \u0e23\u0e39\u0e1b\u0e41\u0e1a\u0e1a\u0e2a\u0e31\u0e07\u0e40\u0e04\u0e23\u0e32\u0e30\u0e2b\u0e4c\u0e40\u0e23\u0e35\u0e22\u0e01\u0e27\u0e48\u0e32 thymalfasin \u0e41\u0e25\u0e30\u0e21\u0e35 ZADAXIN \u0e40\u0e1b\u0e47\u0e19\u0e0a\u0e37\u0e48\u0e2d\u0e01\u0e32\u0e23\u0e04\u0e49\u0e32\u0e2b\u0e19\u0e36\u0e48\u0e07 \u0e1c\u0e25\u0e01\u0e32\u0e23\u0e28\u0e36\u0e01\u0e29\u0e32\u0e43\u0e19\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e40\u0e09\u0e1e\u0e32\u0e30\u0e42\u0e23\u0e04\u0e22\u0e31\u0e07\u0e43\u0e0a\u0e49\u0e23\u0e31\u0e1a\u0e23\u0e2d\u0e07\u0e01\u0e32\u0e23\u0e40\u0e2a\u0e23\u0e34\u0e21\u0e20\u0e39\u0e21\u0e34\u0e2b\u0e23\u0e37\u0e2d\u0e0a\u0e30\u0e25\u0e2d\u0e27\u0e31\u0e22\u0e43\u0e19\u0e04\u0e19\u0e17\u0e31\u0e48\u0e27\u0e44\u0e1b\u0e44\u0e21\u0e48\u0e44\u0e14\u0e49","_links":{"self":[{"href":"https:\/\/www.musclestationth.com\/en\/wp-json\/wp\/v2\/posts\/12043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.musclestationth.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.musclestationth.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.musclestationth.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.musclestationth.com\/en\/wp-json\/wp\/v2\/comments?post=12043"}],"version-history":[{"count":2,"href":"https:\/\/www.musclestationth.com\/en\/wp-json\/wp\/v2\/posts\/12043\/revisions"}],"predecessor-version":[{"id":12045,"href":"https:\/\/www.musclestationth.com\/en\/wp-json\/wp\/v2\/posts\/12043\/revisions\/12045"}],"wp:attachment":[{"href":"https:\/\/www.musclestationth.com\/en\/wp-json\/wp\/v2\/media?parent=12043"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.musclestationth.com\/en\/wp-json\/wp\/v2\/categories?post=12043"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.musclestationth.com\/en\/wp-json\/wp\/v2\/tags?post=12043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}